Author Wegwitz, Florian
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2024 | Preprint
Enhancement of colorectal cancer therapy through interruption of the HSF1-HSP90 axis by p53 activation or cell cycle inhibition
Isermann, T.; Schneider, K. L.; Wegwitz, F.; De Oliveira, T.; Conradi, L.-C.; Volk, V.& Feuerhake, F. et al. (2024). DOI: https://doi.org/10.1101/2024.02.22.581507
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2024 | Journal Article |
USP22 supports the aggressive behavior of basal-like breast cancer by stimulating cellular respiration
Prokakis, E.; Bamahmoud, H.; Jansari, S.; Fritsche, L.; Dietz, A.; Boshnakovska, A. & Rehling, P. et al. (2024)
Cell Communication and Signaling, 22(1) art. 120. DOI: https://doi.org/10.1186/s12964-023-01441-5
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2023 | Journal Article |
Basal‐like mammary carcinomas stimulate cancer stem cell properties through AXL‐signaling to induce chemotherapy resistance
Pantelaiou‐Prokaki, G.; Reinhardt, O.; Georges, N. S.; Agorku, D. J.; Hardt, O.; Prokakis, E. & Mieczkowska, I. K. et al. (2023)
International Journal of Cancer, 152(9) art. ijc.34429. DOI: https://doi.org/10.1002/ijc.34429
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2023 | Journal Article |
RNF40 epigenetically modulates glycolysis to support the aggressiveness of basal-like breast cancer
Prokakis, E.; Jansari, S.; Boshnakovska, A.; Wiese, M.; Kusch, K.; Kramm, C. & Dullin, C. et al. (2023)
Cell Death & Disease, 14(9). DOI: https://doi.org/10.1038/s41419-023-06157-5
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2022 | Journal Article | Research Paper
HDAC8 suppresses the epithelial phenotype and promotes EMT in chemotherapy-treated basal-like breast cancer
Pantelaiou-Prokaki, G.; Mieczkowska, I.; Schmidt, G. E.; Fritzsche, S.; Prokakis, E.; Gallwas, J. & Wegwitz, F. (2022)
Clinical Epigenetics, 14(1) art. 7. DOI: https://doi.org/10.1186/s13148-022-01228-4
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2022 | Journal Article |
Osmotic Stress Interferes with DNA Damage Response and H2AX Phosphorylation in Human Keratinocytes
Hoen, L.; Rudisch, C.; Wick, M.; Indenbirken, D.; Grundhoff, A.; Wegwitz, F. & Kalkhof, S. et al. (2022)
Cells, 11(6) pp. 959. DOI: https://doi.org/10.3390/cells11060959
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2021 | Journal Article | Research Paper |
Suppression of HSF1 activity by wildtype p53 creates a driving force for p53 loss-of-heterozygosity
Isermann, T.; Şener, Ö. Ç.; Stender, A.; Klemke, L.; Winkler, N.; Neesse, A. & Li, J. et al. (2021)
Nature Communications, 12(1) art. 4019. DOI: https://doi.org/10.1038/s41467-021-24064-1
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2021 | Journal Article
TNF-α-producing macrophages determine subtype identity and prognosis via AP1 enhancer reprogramming in pancreatic cancer
Tu, M.; Klein, L.; Espinet, E.; Georgomanolis, T.; Wegwitz, F.; Li, X. & Urbach, L. et al. (2021)
Nature Cancer, 2(11) pp. 1185-1203. DOI: https://doi.org/10.1038/s43018-021-00258-w
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2021 | Journal Article |
USP22 promotes HER2-driven mammary carcinoma aggressiveness by suppressing the unfolded protein response
Prokakis, E.; Dyas, A.; Grün, R.; Fritzsche, S.; Bedi, U.; Kazerouni, Z. B. & Kosinsky, R. L. et al. (2021)
Oncogene,. DOI: https://doi.org/10.1038/s41388-021-01814-5
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2019 | Journal Article |
The histone methyltransferase DOT1L is required for proper DNA damage response, DNA repair, and modulates chemotherapy responsiveness
Kari, V.; Raul, S. K; Henck, J. M; Kitz, J.; Kramer, F.; Kosinsky, R. L & Übelmesser, N. et al. (2019)
Clinical Epigenetics, 11(1) art. 4. DOI: https://doi.org/10.1186/s13148-018-0601-1
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2019 | Journal Article |
The E3 ubiquitin ligase RNF40 suppresses apoptosis in colorectal cancer cells
Schneider, D.; Chua, R. L; Molitor, N.; Hamdan, F. H; Rettenmeier, E. M; Prokakis, E. & Mishra, V. K et al. (2019)
Clinical Epigenetics, 11(1) art. 98. DOI: https://doi.org/10.1186/s13148-019-0698-x
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2017 | Journal Article |
Histone deacetylase class-I inhibition promotes epithelial gene expression in pancreatic cancer cells in a BRD4-and MYC-dependent manner
Mishra, V. K.; Wegwitz, F.; Kosinsky, R. L.; Sen, M. ; Baumgartner, R.; Wulff, T. & Siveke, J. T. et al. (2017)
Nucleic Acids Research, 45(11) pp. 6334-6349. DOI: https://doi.org/10.1093/nar/gkx212
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2017 | Journal Article |
BRD4 promotes p63 and GRHL3 expression downstream of FOXO in mammary epithelial cells
Nagarajan, S.; Bedi, U.; Budida, A. ; Hamdan, F. H. ; Mishra, V. K.; Najafova, Z. & Xie, W. et al. (2017)
Nucleic Acids Research, 45(6) pp. 3130-3145. DOI: https://doi.org/10.1093/nar/gkw1276
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2017 | Journal Article |
RNF40 regulates gene expression in an epigenetic context-dependent manner
Xie, W.; Nagarajan, S.; Baumgart, S. J.; Kosinsky, R. L.; Najafova, Z.; Kari, V. & Hennion, M. et al. (2017)
Genome Biology, 18 art. 32. DOI: https://doi.org/10.1186/s13059-017-1159-5
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2016 | Conference Abstract
Kruppel-like Transcription Factor-10 (KLF10) suppresses the TGF beta-induced epithelial-to-mesenchymal transition
Mishra, V. K.; Kari, V.; Subramaniam, M.; Baumgart, S. J.; Nagarajan, S.; Wegwitz, F. & Spelsberg, T. C. et al. (2016)
Cancer Research, 76 American-Association-for-Cancer-Research (AACR) Special Conference on Chromatin and Epigenetics in Cancer, Atlanta, GA.
Philadelphia: Amer Assoc Cancer Research. DOI: https://doi.org/10.1158/1538-7445.CHROMEPI15-A03
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2016 | Journal Article
Histone Chaperone SSRP1 is Essential for Wnt Signaling Pathway Activity During Osteoblast Differentiation
Hossan, T.; Nagarajan, S.; Baumgart, S. J.; Xie, W. ; Magallanes, R. T.; Hernandez, C. & Chiaroni, P.-M. et al. (2016)
Stem Cells, 34(5) pp. 1369-1376. DOI: https://doi.org/10.1002/stem.2287
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2016 | Journal Article
Exosomal cellular prion protein drives fibrillization of amyloid beta and counteracts amyloid beta-mediated neurotoxicity
Falker, C.; Hartmann, A. K.; Guett, I.; Dohler, F.; Altmeppen, H.; Betzel, C. & Schubert, R. et al. (2016)
Journal of Neurochemistry, 137(1) pp. 88-100. DOI: https://doi.org/10.1111/jnc.13514
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2016 | Journal Article |
CEACAM1 controls the EMT switch in murine mammary carcinoma in vitro and in vivo
Wegwitz, F.; Lenfert, E.; Gerstel, D.; von Ehrenstein, L.; Einhoff, J.; Schmidt, G. & Logsdon, M. et al. (2016)
Oncotarget, 7(39) pp. 63730-63746. DOI: https://doi.org/10.18632/oncotarget.11650
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2015 | Journal Article |
Usp22 deficiency impairs intestinal epithelial lineage specification in vivo.
Kosinsky, R. L.; Wegwitz, F.; Hellbach, N.; Dobbelstein, M. ; Mansouri, A.; Vogel, T. & Begus-Nahrmann, Y. et al. (2015)
Oncotarget, 6(35) pp. 37906-37918. DOI: https://doi.org/10.18632/oncotarget.5412
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2015 | Journal Article
Chemotherapy of WAP-T mouse mammary carcinomas aggravates tumor phenotype and enhances tumor cell dissemination
Jannasch, K.; Wegwitz, F.; Lenfert, E.; Maenz, C.; Deppert, W. R. & Alves, F. (2015)
International Journal of Cancer, 137(1) pp. 25-36. DOI: https://doi.org/10.1002/ijc.29369
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